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Vasodilators, 1 -receptor antagonists, 2 -receptor agonists, and postganglionic adrenergic neuron blockers should be avoided as initial agents for hypertension

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Mollerherm H, Branitzki-Heinemann K, Brogden G, Elamin AA, Oehlmann W, Fuhrmann H, Singh M, Naim HY, von Kockritz-Blickwede M (2017) Hypoxia modulates the response of mast cells to Staphylococcus aureus infection

In severe cases, adults may develop osteomalacia (soft bones), whilst children may develop rickets Fatigue and low mood : Persistent tiredness and depressive symptoms, though there is no official link definitively established between vitamin D levels and mood disorders Increased infection susceptibility : Some evidence suggests a link with recurrent respiratory infections, though clinical trial evidence is mixed and benefits appear modest Hair loss : Some observational studies have associated diffuse hair thinning with low vitamin D levels, though this relationship requires further research Vitamin B12 deficiency typically develops gradually and can cause significant neurological and haematological complications: Anaemia symptoms : Fatigue, pallor, shortness of breath, and palpitations due to megaloblastic anaemia Neurological manifestations : Paraesthesia (pins and needles), particularly in hands and feet